The effects of potassium supplements , spironolactone or amiloride on the potassium status of patients with heart failure
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چکیده
Extra potassium supplements, spironolactone or amiloride were given for 5 months to forty-nine patients with heart failure who were taking furosemide and were in a steady state. Plasma potassium increased with all three treatments but there was no significant increase in total body potassium or red cell potassium. These findings together with other studies suggest that patients with heart failure taking diuretics do not have a significant depletion of body potassium.
منابع مشابه
The effects of potassium supplements, spironolactone of amiloride on the potassium status of patients with heart failure.
Extra potassium supplements, spironolactone or amiloride were given for 5 months to forty-nine patients with heart failure who were taking furosemide and were in a steady state. Plasma potassium increased with all three treatments but there was no significant increase in total body potassium or red cell potassium. These findings together with other studies suggest that patients with heart failu...
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Objectives: To test whether simply increasing plasma potassium with amiloride would exert any of the same beneficial effects on “surrogate outcome measures” that are seen with spironolactone. The latter has been shown to improve mortality in chronic heart failure, possibly as a result of improvements in endothelial dysfunction, vascular angiotensin converting enzyme (ACE), autonomic function, m...
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The renin-angiotensin-aldosterone system and electrolyte levels in 11 patients with heart failure controlled on digoxin and frusemide were investigated after separate periods of Slow K, spironolactone, and amiloride therapy. When spironolactone or amiloride replaced Slow K, distinct parallel increments in the levels of renin, angiotensin II, and aldosterone resulted. Though plasma potassium was...
متن کاملProgressive hypokalaemia in elderly patients taking three thiazide potassium-sparing diuretic combinations for thirty-six months.
Three different thiazide potassium-sparing diuretic combinations were given to elderly patients for heart failure. Eighty patients received their allocated combinations for 3 years and had 6-monthly measurements of plasma potassium. A further 84 were recruited for study but 29 died within 6 months and 55 had to be withdrawn from the trial. The triamterene-containing preparation was discontinued...
متن کاملAssociation of aldosterone concentration and mineralocorticoid receptor genotype with potassium response to spironolactone in patients with heart failure.
STUDY OBJECTIVE To identify patient-specific factors associated with spironolactone-induced potassium level elevation in patients with heart failure. DESIGN Prospective cohort study. SETTING Two adult heart failure clinics. PATIENTS Sixty-two adult (mean +/- SD age 54 +/- 16 yrs) aldosterone antagonist-naïve patients with heart failure. INTERVENTION Patients received spironolactone 12.5...
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